Design, synthesis, and herbicidal evaluation of pyrrolidinone-containing 2‑phenylpyridine derivatives as novel protoporphyrinogen oxidase inhibitors

• Main Authors: Zhang, Meng, Cai, Hui, Pang, Chen, Chen, Zhongyin, Ling, Dan, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Herbicidal activity; Enzyme activity
• Online Access: https://hdl.handle.net/10356/179408
• Institution: Nanyang Technological University

In this work, a series of pyrrolidinone-containing 2-phenylpyridine derivatives were synthesized and evaluated as novel protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) inhibitors for herbicide development. At 150 g ai/ha, compounds 4d, 4f, and 4l can inhibit the grassy weeds of Echinochloa crus-gall...