Harnessing croconaine organic photosensitizers for a milder surface-mediated transfection

Harnessing croconaine organic photosensitizers for a milder surface-mediated transfection

Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An o...

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Bibliographic Details
Main Authors: Ferdinandus, Tan, Lenice Wen Ling, Tan, Jie Ren, Lee, Hiang Kwee, Zhu, Qiang, Ye, Enyi, Lee, Ken Chi-Lik
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Organic photosensitizer
Photothermal
Online Access:https://hdl.handle.net/10356/179529
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Institution: Nanyang Technological University
Language: English
Description
Summary:Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.

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