Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma
Natural killer/T cell lymphoma (NKTL) is an aggressive malignancy associated with poor prognosis. This is largely due to limited treatment options, especially for relapsed patients. Immunotherapies like immune checkpoint inhibitors (ICI) and anti-CD38 therapies have shown promising but variable clin...
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sg-ntu-dr.10356-1797052024-08-19T15:32:18Z Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma Lee, Wendy W. L. Lim, Jing Quan Tang, Tiffany Pooi Ling Tan, Daryl Koh, Ser Mei Puan, Kia Joo Wang, Liang Wei Lim, Jackwee Tan, Kim Peng Chng, Wee Joo Lim, Soon Thye Ong, Choon Kiat Rotzschke, Olaf School of Biological Sciences Medicine, Health and Life Sciences Immunotherapy Lymphoma Natural killer/T cell lymphoma (NKTL) is an aggressive malignancy associated with poor prognosis. This is largely due to limited treatment options, especially for relapsed patients. Immunotherapies like immune checkpoint inhibitors (ICI) and anti-CD38 therapies have shown promising but variable clinical efficacies. Combining these therapies has been suggested to enhance efficacy. Agency for Science, Technology and Research (A*STAR) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version The study was supported by the Biomedical Research Council, A*STAR and Singapore Ministry of Health’s National Medical Research Council (NMRC-OFLCG-18May0028). OR and JWL grants are supported by A*STAR IAF-PP H22J2a0043 and A*STAR JCO (Grant ID: 222D89) respectively. LW and JQL are supported by MOHOFYIRG19nov-0013 and MOH-OFYIRG22jul-0017 respectively 2024-08-19T05:10:42Z 2024-08-19T05:10:42Z 2024 Journal Article Lee, W. W. L., Lim, J. Q., Tang, T. P. L., Tan, D., Koh, S. M., Puan, K. J., Wang, L. W., Lim, J., Tan, K. P., Chng, W. J., Lim, S. T., Ong, C. K. & Rotzschke, O. (2024). Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma. Frontiers in Immunology, 15, 1346178-. https://dx.doi.org/10.3389/fimmu.2024.1346178 1664-3224 https://hdl.handle.net/10356/179705 10.3389/fimmu.2024.1346178 38680487 2-s2.0-85191293905 15 1346178 en NMRC-OFLCG-18May0028 222D89 MOHOFYIRG19nov-0013 MOH-OFYIRG22jul-0017 NRF2017_SISFP09 Frontiers in Immunology © 2024 Lee, Lim, Tang, Tan, Koh, Puan, Wang, Lim, Tan, Chng, Lim, Ong and Rotzschke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Nanyang Technological University |
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Singapore Singapore |
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Medicine, Health and Life Sciences Immunotherapy Lymphoma |
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Medicine, Health and Life Sciences Immunotherapy Lymphoma Lee, Wendy W. L. Lim, Jing Quan Tang, Tiffany Pooi Ling Tan, Daryl Koh, Ser Mei Puan, Kia Joo Wang, Liang Wei Lim, Jackwee Tan, Kim Peng Chng, Wee Joo Lim, Soon Thye Ong, Choon Kiat Rotzschke, Olaf Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| description |
Natural killer/T cell lymphoma (NKTL) is an aggressive malignancy associated with poor prognosis. This is largely due to limited treatment options, especially for relapsed patients. Immunotherapies like immune checkpoint inhibitors (ICI) and anti-CD38 therapies have shown promising but variable clinical efficacies. Combining these therapies has been suggested to enhance efficacy. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Lee, Wendy W. L. Lim, Jing Quan Tang, Tiffany Pooi Ling Tan, Daryl Koh, Ser Mei Puan, Kia Joo Wang, Liang Wei Lim, Jackwee Tan, Kim Peng Chng, Wee Joo Lim, Soon Thye Ong, Choon Kiat Rotzschke, Olaf |
| format |
Article |
| author |
Lee, Wendy W. L. Lim, Jing Quan Tang, Tiffany Pooi Ling Tan, Daryl Koh, Ser Mei Puan, Kia Joo Wang, Liang Wei Lim, Jackwee Tan, Kim Peng Chng, Wee Joo Lim, Soon Thye Ong, Choon Kiat Rotzschke, Olaf |
| author_sort |
Lee, Wendy W. L. |
| title |
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| title_short |
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| title_full |
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| title_fullStr |
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| title_full_unstemmed |
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma |
| title_sort |
counterproductive effects of anti-cd38 and checkpoint inhibitor for the treatment of nk/t cell lymphoma |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/179705 |
| _version_ |
1814047326017159168 |