Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria

Hydrogen peroxide is widely used to remedy bacterial and parasitic infections, but its excessive use will cause severe damage to aquatic animals. Moreover, there is no safe, efficient and low-cost method to degrade residual hydrogen peroxide in water. Here we developed a hydrogen peroxide removal me...

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Main Authors: Han, Shuo, Qin, Mengyuan, Wang, Yuqi, Gao, Chao, Niu, Wenfang, Han, Jingjing, Wang, Hailei, Li, Yi
Other Authors: Nanyang Environment and Water Research Institute
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/180201
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1802012024-09-24T01:02:51Z Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria Han, Shuo Qin, Mengyuan Wang, Yuqi Gao, Chao Niu, Wenfang Han, Jingjing Wang, Hailei Li, Yi Nanyang Environment and Water Research Institute Advanced Environmental Biotechnology Center Earth and Environmental Sciences Membrane permeability Environmental remediation Hydrogen peroxide is widely used to remedy bacterial and parasitic infections, but its excessive use will cause severe damage to aquatic animals. Moreover, there is no safe, efficient and low-cost method to degrade residual hydrogen peroxide in water. Here we developed a hydrogen peroxide removal mechanism by which autoinducer-2 (AI-2), a quorum sensing signal molecule that can promote the hydrogen peroxide degradation by Gram-positive bacteria. Here, we investigated the promotion effect of AI-2 on hydrogen peroxide degradation by Deinococcus sp. Y35 and the response of the antioxidant system. We further sought to understand the key mechanism underlying the promotion effect of AI-2 on hydrogen peroxide degradation is that, AI-2 contributed to the resistance of strain Y35 to oxidative stress induced by hydrogen peroxide, and altered membrane permeability of strain Y35 that allowed more hydrogen peroxide to enter bacterial cells and be degraded. Additionally, AI-2 can also encourage multiple Gram-positive bacteria to degrade hydrogen peroxide. Accordingly, our study serves as a reference for the regulation mechanism of the signal molecule AI-2 and provides the development of new strategies for hydrogen peroxide degradation. This work is supported by the National Natural Science Foundation of China (32000073) and the Key Scientific Research Programs of Henan Education Department (21A180011). 2024-09-24T01:02:51Z 2024-09-24T01:02:51Z 2024 Journal Article Han, S., Qin, M., Wang, Y., Gao, C., Niu, W., Han, J., Wang, H. & Li, Y. (2024). Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria. Journal of Hazardous Materials, 466, 133582-. https://dx.doi.org/10.1016/j.jhazmat.2024.133582 0304-3894 https://hdl.handle.net/10356/180201 10.1016/j.jhazmat.2024.133582 38280328 2-s2.0-85183489051 466 133582 en Journal of Hazardous Materials © 2024 Elsevier B.V. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Earth and Environmental Sciences
Membrane permeability
Environmental remediation
spellingShingle Earth and Environmental Sciences
Membrane permeability
Environmental remediation
Han, Shuo
Qin, Mengyuan
Wang, Yuqi
Gao, Chao
Niu, Wenfang
Han, Jingjing
Wang, Hailei
Li, Yi
Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
description Hydrogen peroxide is widely used to remedy bacterial and parasitic infections, but its excessive use will cause severe damage to aquatic animals. Moreover, there is no safe, efficient and low-cost method to degrade residual hydrogen peroxide in water. Here we developed a hydrogen peroxide removal mechanism by which autoinducer-2 (AI-2), a quorum sensing signal molecule that can promote the hydrogen peroxide degradation by Gram-positive bacteria. Here, we investigated the promotion effect of AI-2 on hydrogen peroxide degradation by Deinococcus sp. Y35 and the response of the antioxidant system. We further sought to understand the key mechanism underlying the promotion effect of AI-2 on hydrogen peroxide degradation is that, AI-2 contributed to the resistance of strain Y35 to oxidative stress induced by hydrogen peroxide, and altered membrane permeability of strain Y35 that allowed more hydrogen peroxide to enter bacterial cells and be degraded. Additionally, AI-2 can also encourage multiple Gram-positive bacteria to degrade hydrogen peroxide. Accordingly, our study serves as a reference for the regulation mechanism of the signal molecule AI-2 and provides the development of new strategies for hydrogen peroxide degradation.
author2 Nanyang Environment and Water Research Institute
author_facet Nanyang Environment and Water Research Institute
Han, Shuo
Qin, Mengyuan
Wang, Yuqi
Gao, Chao
Niu, Wenfang
Han, Jingjing
Wang, Hailei
Li, Yi
format Article
author Han, Shuo
Qin, Mengyuan
Wang, Yuqi
Gao, Chao
Niu, Wenfang
Han, Jingjing
Wang, Hailei
Li, Yi
author_sort Han, Shuo
title Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
title_short Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
title_full Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
title_fullStr Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
title_full_unstemmed Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria
title_sort quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by gram-positive bacteria
publishDate 2024
url https://hdl.handle.net/10356/180201
_version_ 1814047207691649024