The LIDPAD mouse model captures the multisystem interactions and extrahepatic complications in MASLD

• Main Authors: Low, Zun Siong, Chua, Damien, Cheng, Hong Sheng, Tee, Rachel, Tan, Wei Ren, Ball, Christopher, Norliza Binte Esmail Sahib, Ng, Ser Sue, Qu, Jing, Liu, Yingzi, Hong, Haiyu, Cai, Chaonong, Rao, Nandini Chilagondanahalli Lakshmi, Wee, Aileen, Muthiah, Mark Dhinesh, Bichler, Zoë, Mickelson, Barbara, Kong, Mei Suen, Tay, Vanessa Shiyun, Yan, Zhuang, Chen, Jiapeng, Ng, Aik Seng, Yip, Yun Sheng, Vos, Marcus Ivan Gerard, Tan, Nicole Ashley, Lim, Dao Liang, Lim, Debbie Xiu En, Chittezhath, Manesh, Yaligar, Jadegoud, Verma, Sanjay Kumar, Poptani, Harish, Guan, Xue Li, Velan, Sambasivam Sendhil, Ali, Yusuf, Li, Liang, Tan, Nguan Soon, Wahli, Walter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Diet-induced weight loss; Gut microbiome
• Online Access: https://hdl.handle.net/10356/180405
• Institution: Nanyang Technological University

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic the human disease and its comorbidities. The liver disease progressio...