Profiling of blood-based transcriptomics and multimodal modelling of clinical outcome in ultra-high-risk individuals from the LYRIKS cohort

• Main Author: Tan, Samuel Ming Xuan
• Other Authors: Goh Wen Bin Wilson
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; Mental health; Psychosis; RNA-seq; Ultra-high-risk; Schizophrenia; Clinical outcome prediction
• Online Access: https://hdl.handle.net/10356/180555
• Institution: Nanyang Technological University

Psychosis is the defining characteristic of schizophrenia spectrum and psychotic disorders (American Psychiatric Association, 2013). The onset of psychosis is often preceded by a period of subthreshold symptoms commonly referred to as the prodrome (Yung et al., 1996). Individuals identified to be in...