Physiologic medium renders human iPSC-derived macrophages permissive for M. tuberculosis by rewiring organelle function and metabolism

• Main Authors: Bussi, Claudio, Lai, Rachel, Athanasiadi, Natalia, Gutierrez, Maximiliano G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Macrophages; Mycobacterium tuberculosis
• Online Access: https://hdl.handle.net/10356/180572
• Institution: Nanyang Technological University

In vitro studies are crucial for our understanding of the human macrophage immune functions. However, traditional in vitro culture media poorly reflect the metabolic composition of blood, potentially affecting the outcomes of these studies. Here, we analyzed the impact of a physiological medium on h...