In-situ activation of biomimetic single-site bioorthogonal nanozyme for tumor-specific combination therapy

• Main Authors: Ma, Mengmeng, Yuan, Wei, Zhong, Wenbin, Cheng, Yu, Yao, Haochen, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Click chemistry; Cell-specific therapy
• Online Access: https://hdl.handle.net/10356/180646
• Institution: Nanyang Technological University

Copper-catalyzed click chemistry offers creative strategies for activation of therapeutics without disrupting biological processes. Despite tremendous efforts, current copper catalysts face fundamental challenges in achieving high efficiency, atom economy, and tissue-specific selectivity. Herein, we...