Profiling pro-inflammatory proteases as biomolecular signature of material-induced subcutaneous host response in immuno-competent mice

• Main Authors: Tran, Nam M. P., Truong, Anh T. H., Nguyen, Dang T., Dang, Tram Thuy
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Protease; Subcutaneous implant; Biomaterial; Host immune response; Inflammation
• Online Access: https://hdl.handle.net/10356/180852
• Institution: Nanyang Technological University

Proteases are important modulators of inflammation, but they remain understudied in material-induced immune response, which is critical to clinical success of biomedical implants. Herein, we comprehensively profile molecular expression and proteolytic activity of three distinct proteases, namely neu...