Dual-locked enzyme-activatable bioorthogonal fluorescence turn-on imaging of senescent cancer cells

• Main Authors: Wang, Xinzhu, Liew, Si Si, Huang, Jingsheng, Hu, Yuxuan, Wei, Xin, Pu, Kanyi
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cancer cells; Fluorescence imaging
• Online Access: https://hdl.handle.net/10356/180907
• Institution: Nanyang Technological University

Bioorthogonal pretargeting optical imaging shows the potential for enhanced diagnosis and prognosis. However, the bioorthogonal handles, known for being "always reactive", may engage in reactions at unintended sites with their counterparts, resulting in nonspecific fluorescence activation...