A Wurster-type covalent organic framework with internal electron transfer-enhanced catalytic capacity for tumor therapy

• Main Authors: Liu, Yang, Zhao, Huan, Wang, Shihuai, Niu, Rui, Bi, Shuai, Han, Wang-Kang, Wang, Yinghui, Song, Shuyan, Zhang, Hongjie, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Wurster-Type Covalent Organic Framework; Antineoplastic agent
• Online Access: https://hdl.handle.net/10356/181008
• Institution: Nanyang Technological University

The low immunogenicity of tumors, along with the abnormal structural and biochemical barriers of tumor-associated vasculature, impedes the infiltration and function of effector T cells at the tumor site, severely inhibiting the efficacy of antitumor immunotherapy. In this study, a cobaloxime catalys...