Lgr5 marks stem/progenitor cells contributing to epithelial and muscle development in the mouse esophagus

• Main Authors: Kostic, Lana, Leung, Carly, Murad, Katzrin Ahmad, Kancheva, Snezhina, Perna, Stefano, Lee, Bernett, Barker, Nick
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Epithelium cell; Esophagus muscle
• Online Access: https://hdl.handle.net/10356/181252
• Institution: Nanyang Technological University

The existence and function of Lgr5+ cells within the developing esophagus remains unknown. Here, we document multiple discrete Lgr5+ populations in the developing mouse esophagus, predominantly within nascent epithelial and external muscle layers. Lgr5 expression initially emerges in the developing...