A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis

• Main Authors: Putera, Ikhwanuliman, Schrijver, Benjamin, Kolijn, P. Martijn, van Stigt, Astrid C., Ten Berge, Josianne C. E. M., IJspeert, Hanna, Nagtzaam, Nicole M. A., Swagemakers, Sigrid M. A., van Laar, Jan A. M., Agrawal, Rupesh, Rombach, Saskia M., van Hagen, P. Martin, La Distia Nora, Rina, Dik, Willem A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Sarcoidosis; Tuberculosis
• Online Access: https://hdl.handle.net/10356/181307
• Institution: Nanyang Technological University

Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two distinct geographically separated cohorts: sarcoidosis from t...