Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis

• Main Authors: Ng, Qing Yong, Mahendran, Vikneswari, Lim, Ze Qin, Tan, Jasmine Hwee Yee, Wong, Joel Jie Feng, Chu, Justin Jang Hann, Chow, Vincent T. K., Sze, Newman Siu Kwan, Alonso, Sylvie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Foot and Mouth Disease; Enterovirus A71
• Online Access: https://hdl.handle.net/10356/181308
• Institution: Nanyang Technological University

Background: Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained elusive. Methods: A siRNA screen in EV-A71 infected-motor neurons was performed t...