NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics

• Main Authors: Choi, Youngjoo, Saron, Wilfried A. A., O'Neill, Aled, Senanayake, Manouri, Wilder-Smith, Annelies, Rathore, Abhay P. S., St John, Ashley L.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Dengue; Immunological memory
• Online Access: https://hdl.handle.net/10356/181378
• Institution: Nanyang Technological University

NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their contributions to long-term immune memory to viruses are unclear. We identified granzyme K, a product made by cytotoxic cells including NKT cells, as linked to induction of Th1-associated antibodies during prim...