Association between kidney disease index and decline in cognitive function with mediation by arterial stiffness in Asians with type 2 diabetes

• Main Authors: Low, Serena, Moh, Angela, Goh, Kiat Sern, Khoo, Jonathon, Ang, Keven, Liu, Allen Yan Lun, Tang, Wern Ee, Lim, Ziliang, Subramaniam, Tavintharan, Sum, Chee Fang, Lim, Su Chi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Kidney disease index; Cognitive function
• Online Access: https://hdl.handle.net/10356/181470
• Institution: Nanyang Technological University

Background: Decline in renal function impairs systemic clearance of amyloid-β which characterizes Alzheimer's disease while albuminuria is associated with blood-brain barrier disruption due to endothelial damage. Arterial stiffness adversely affects the brain with high pulsatile flow damaging c...