Exclusive solvent-controlled regioselective catalytic synthesis of potentially bioactive imidazolidineiminodithiones: NMR analysis, computational studies and X-ray crystal structures

• Main Authors: Moussa, Ziad, Saada, Sara, Paz, Alejandro Perez, Alzamly, Ahmed, Judeh, Zaher M. A., Alshehhi, Aaesha R., Khudhair, Aisha, Almheiri, Salama A., Al-Masri, Harbi Tomah, Ahmed, Saleh A.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Isothiocyanates; Imidazolidineiminodithiones
• Online Access: https://hdl.handle.net/10356/181589
• Institution: Nanyang Technological University

Herein, we describe the first consistent regiospecific reaction of isothiocyanates with a variety of substituted N-arylcyanothioformamides in a 1:1 molar ratio to generate a series of imidazolidineiminodithiones decorated with a multitude of functional groups on both aromatic rings. The reaction is...