Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer

• Main Authors: Zhao, Yi, Li, Shangru, Zhu, Lefan, Huang, Mingle, Xie, Yubin, Song, Xinming, Chen, Zhihui, Lau, Harry Cheuk-Hay, Sung, Joseph Jao Yiu, Xu, Lixia, Yu, Jun, Li, Xiaoxing
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Chemotherapy; Gastric cancer
• Online Access: https://hdl.handle.net/10356/181601
• Institution: Nanyang Technological University

The efficacy of chemotherapy varies significantly among patients with gastric cancer (GC), and there is currently no effective strategy to predict chemotherapeutic outcomes. In this study, we successfully establish 57 GC patient-derived organoids (PDOs) from 73 patients with GC (78%). These organoid...