Novel functions of integrated stress response proteins on collided ribosomes

• المؤلف الرئيسي: Chan, Tristan Yew Kit
• مؤلفون آخرون: Choe Young Jun
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2024
• الموضوعات: Medicine, Health and Life Sciences; Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/181788
• المؤسسة: Nanyang Technological University

Ribosome stalling during translation can lead to ribosome collisions, providing a platform for the ribosome-associated quality control (RQC) and the integrated stress response (ISR) pathways. RQC dissociates stalled ribosomes through Hel2-mediated ubiquitylation of the small ribosome subunit protein...