Intratumoral transforming boron nanosensitizers for amplifiedboron neutron capture therapy

• Main Authors: Li, Liping, Wang, Mixue, Zhao, Qian, Bai, Peirong, Hao, Haotian, Zhang, Zizhu, Liu, Tong, Yang, Yongzhen, Pu, Kanyi, Zhang, Ruiping
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Medicine, Health and Life Sciences; Boron neutron capture therapy; Boron nanosensitizers
• Online Access: https://hdl.handle.net/10356/181952
• Institution: Nanyang Technological University

Boron neutron capture therapy (BNCT) is an advanced binary tumor-cell-selected heavy-particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor-specific accumulation of boron agents. To tackle...