Intratumoral transforming boron nanosensitizers for amplifiedboron neutron capture therapy

• Main Authors: Li, Liping, Wang, Mixue, Zhao, Qian, Bai, Peirong, Hao, Haotian, Zhang, Zizhu, Liu, Tong, Yang, Yongzhen, Pu, Kanyi, Zhang, Ruiping
• 其他作者: School of Chemistry, Chemical Engineering and Biotechnology
• 格式: Article
• 語言: English
• 出版: 2025
• 主題: Chemistry; Medicine, Health and Life Sciences; Boron neutron capture therapy; Boron nanosensitizers
• 在線閱讀: https://hdl.handle.net/10356/181952
• 機構: Nanyang Technological University

Boron neutron capture therapy (BNCT) is an advanced binary tumor-cell-selected heavy-particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor-specific accumulation of boron agents. To tackle...