Development of physiological-based pharmacokinetic model 1 - model synthesis

• Main Author: Tan, Lisa Ying Xiu.
• Other Authors: Koh Tong San
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/18196
• Institution: Nanyang Technological University

This project aims to improve on an existing physiological-based pharmacokinetic (PBPK) model on rats for drug candidate diazepam. The existing PBPK model has large discrepancy with the experimental results especially on the hepatic and gut tissue drug concentration. The existing PBPK discuss on intr...