π-π interactions drive the homotypic phase separation of the prion-like diatom pyrenoid scaffold PYCO1

• Main Authors: Poh, Cheng Wei, Mueller-Cajar, Oliver
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; CO2 fixation; Biomolecular condensation
• Online Access: https://hdl.handle.net/10356/181983
• Institution: Nanyang Technological University

CO2 fixation in most unicellular algae relies on the pyrenoid, a biomolecular condensate, which sequesters the cell's carboxylase Rubisco. In the marine diatom Phaeodactylum tricornutum, the pyrenoid tandem repeat protein Pyrenoid Component 1 (PYCO1) multivalently binds Rubisco to form a hetero...