Prediction of conformational states in a coronavirus channel using Alphafold-2 and DeepMSA2: strengths and limitations

• Main Authors: Torres, Jaume, Pervushin, Konstantin, Surya, Wahyu
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Coronavirus; Envelope protein
• Online Access: https://hdl.handle.net/10356/182072
• Institution: Nanyang Technological University

The envelope (E) protein is present in all coronavirus genera. This protein can form pentameric oligomers with ion channel activity which have been proposed as a possible therapeutic target. However, high resolution structures of E channels are limited to those of the severe acute respiratory syndro...