Machine learning-based prediction of DNA G-quadruplex folding topology with G4ShapePredictor

• Main Authors: Liew, Donn, Lim, Zi Way, Yong, Ee Hou
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2025
• 主題: Computer and Information Science; Medicine, Health and Life Sciences; Circular dichroism; Conformation
• 在線閱讀: https://hdl.handle.net/10356/182077
• 機構: Nanyang Technological University

Deoxyribonucleic acid (DNA) is able to form non-canonical four-stranded helical structures with diverse folding patterns known as G-quadruplexes (G4s). G4 topologies are classified based on their relative strand orientation following the 5' to 3' phosphate backbone polarity. Broadly, G4 to...