Machine learning-based prediction of DNA G-quadruplex folding topology with G4ShapePredictor

• المؤلفون الرئيسيون: Liew, Donn, Lim, Zi Way, Yong, Ee Hou
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2025
• الموضوعات: Computer and Information Science; Medicine, Health and Life Sciences; Circular dichroism; Conformation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/182077

Deoxyribonucleic acid (DNA) is able to form non-canonical four-stranded helical structures with diverse folding patterns known as G-quadruplexes (G4s). G4 topologies are classified based on their relative strand orientation following the 5' to 3' phosphate backbone polarity. Broadly, G4 to...