Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides

• Main Authors: Chang, Denyse Weili, Yoon, Mi-Jeong, Yeo, Kian Hua, Choe, Young-Jun
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Heat shock response; Molecular chaperone
• Online Access: https://hdl.handle.net/10356/182271
• Institution: Nanyang Technological University

Ribosomes translating damaged mRNAs may stall and prematurely split into their large and small subunits. The split large ribosome subunits can continue elongating stalled polypeptides. In yeast, this mRNA-independent translation appends the C-terminal alanine/threonine tail (CAT tail) to stalled pol...