CRISPR-Cas spacer acquisition is a rare event in human gut microbiome

• Main Authors: Zhang, An-Ni, Gaston, Jeffry M., Cárdenas, Pablo, Zhao, Shijie, Gu, Xiaoqiong, Alm, Eric J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; CRISPR-Cas systems; Human gut microbiome
• Online Access: https://hdl.handle.net/10356/182566
• Institution: Nanyang Technological University

Host-parasite relationships drive the evolution of both parties. In microbe-phage dynamics, CRISPR functions as an adaptive defense mechanism, updating immunity via spacer acquisition. Here, we investigated these interactions within the human gut microbiome, uncovering low frequencies of spacer acqu...