Dearomative dimerization of quinolines and their skeletal rearrangement to indoles triggered by single-electron transfer

• Main Authors: Tan, Eugene Yew Kun, Dehdari, Alireza, Lani, Amirah S. Mat, Pratt, Derek A., Chiba, Shunsuke
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Dearomatization; Indoles
• Online Access: https://hdl.handle.net/10356/182573
• Institution: Nanyang Technological University

Dearomatization of two-dimensional planar aromatic feedstocks is an attractive strategy for the introduction of three-dimensional vectors into chemical scaffolds to expand chemical space for drug discovery. Here, we demonstrate the dearomative dimerization and skeletal rearrangement of quinolines un...