Biomolecular modelling of the intrinsically disordered proteins in liquid-liquid phase separation

• 主要作者: Hu, Zixin
• 其他作者: Lu Lanyuan
• 格式: Thesis-Doctor of Philosophy
• 語言: English
• 出版: Nanyang Technological University 2025
• 主題: Chemistry; Computer and Information Science; Medicine, Health and Life Sciences; Other; Biomolecular modelling; Coarse-grained model; Intrinsically disordered proteins/regions; Liquid-liquid phase separation; Molecular dynamics simulation
• 在線閱讀: https://hdl.handle.net/10356/182665
• 機構: Nanyang Technological University

Liquid-liquid phase separation (LLPS) is of significant biological importance and is widely reported in many biological systems. Intrinsically disordered proteins or regions (IDP/Rs) are a class of proteins or regions that lack well-folded structures and are thought to be a major driving force...