Neutrophils - an understudied bystander in dengue?

• Main Authors: Chua, Caroline Lin Lin, Morales, Raika Francesca, Chia, Po Ying, Yeo, Tsin Wen, Teo, Andrew
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Dengue; Neutrophils
• Online Access: https://hdl.handle.net/10356/182706
• Institution: Nanyang Technological University

Dengue is a mosquito-borne viral disease which causes significant morbidity and mortality each year. Previous research has proposed several mechanisms of pathogenicity that mainly involve the dengue virus and host humoral immunity. However, innate immune cells, such as neutrophils, may also play an important role in dengue, albeit a much less defined role. In this review, we discuss the emerging roles of neutrophils in dengue and their involvement in pathologies associated with severe dengue. We also describe the potential use of several neutrophil proteins as biomarkers for severe dengue. These studies suggest that neutrophils are important players in dengue, and a better understanding of neutrophil-dengue biology is urgently needed.