NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death

• Main Authors: Zhang, Tian, Tang, Dongsheng, Wu, Pengfei, Jiang, Shaoping, Zhang, Yuquan, Naeem, Abid, Li, Yong, Li, Chunhui, Hu, Bo, Guo, Shuai, Sun, Caixia, Xiao, Haihua, Yan, Ran, Weng, Yuhua, Huang, Yuanyu
• 其他作者: School of Chemistry, Chemical Engineering and Biotechnology
• 格式: Article
• 語言: English
• 出版: 2025
• 主題: Medicine, Health and Life Sciences; Immunotherapy; Photodynamic therapy
• 在線閱讀: https://hdl.handle.net/10356/183065

Immune checkpoint blockade (ICB) therapy is a widely favored anti-tumor treatment, but it shows limited response to non-immunogenic "cold" tumors and suffers from drug resistance. Photodynamic therapy (PDT), as a powerful localized treatment approach, can convert a "cold tumor" i...