In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer

• المؤلفون الرئيسيون: Vasudevan, Jyothsna, Vijayakumar, Ragavi, Reales-Calderon, Jose Antonio, Lam, Maxine S. Y., Ow, Jin Rong, Aw, Joey, Tan, Damien, Tan, Anthony Tanoto, Bertoletti, Antonio, Adriani, Giulia, Pavesi, Andrea
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2025
• الموضوعات: Medicine, Health and Life Sciences; Liver cancer; Tumor microenvironment
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/183393

The complex tumor microenvironment (TME) presents significant challenges to the development of effective therapies against solid tumors, highlighting the need for advanced in vitro models that better recapitulate TME biology. To address this, we developed a vascularized human liver tumor model using...