In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer

• Main Authors: Vasudevan, Jyothsna, Vijayakumar, Ragavi, Reales-Calderon, Jose Antonio, Lam, Maxine S. Y., Ow, Jin Rong, Aw, Joey, Tan, Damien, Tan, Anthony Tanoto, Bertoletti, Antonio, Adriani, Giulia, Pavesi, Andrea
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Liver cancer; Tumor microenvironment
• Online Access: https://hdl.handle.net/10356/183393
• Institution: Nanyang Technological University

The complex tumor microenvironment (TME) presents significant challenges to the development of effective therapies against solid tumors, highlighting the need for advanced in vitro models that better recapitulate TME biology. To address this, we developed a vascularized human liver tumor model using...