Protein kinase C in regulation of exocytosis
Exocytosis, by which secretory vesicles are directed to outer cell membrane and subsequently discharge their contents upon triggering, is an important and ubiquitous cellular process responsible for secretion of neurotransmitters from neurons and hormones from endocrine cells. Exocytosis is highly r...
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sg-ntu-dr.10356-190092023-03-03T16:00:23Z Protein kinase C in regulation of exocytosis Xue, Renhao Kim Kyong-Tai Chen Peng School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology Exocytosis, by which secretory vesicles are directed to outer cell membrane and subsequently discharge their contents upon triggering, is an important and ubiquitous cellular process responsible for secretion of neurotransmitters from neurons and hormones from endocrine cells. Exocytosis is highly regulated through the orchestrated actions of various proteins and lipids. It has been well recognized that protein kinase Cs (PKCs) are active regulators of exocytosis via phosphorylating multiple key proteins in the exocytotic cascade. The specific actions mediated by PKCs, however, have not been fully elucidated. The challenges mainly lie in the following aspects: 1) large variety of PKC isoforms and dubious specificity of the commonly used pharmacological tools; 2) large variety of PKC substrates; 4) difficulties to isolate the molecular steps in the highly dynamic exocytotic process. DOCTOR OF PHILOSOPHY (SCBE) 2009-09-09T06:42:17Z 2009-09-09T06:42:17Z 2009 2009 Thesis Xue, R. H. (2009). Protein kinase C in regulation of exocytosis. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/19009 10.32657/10356/19009 en 165 p. application/pdf |
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DRNTU::Engineering::Chemical engineering::Biotechnology Xue, Renhao Protein kinase C in regulation of exocytosis |
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Exocytosis, by which secretory vesicles are directed to outer cell membrane and subsequently discharge their contents upon triggering, is an important and ubiquitous cellular process responsible for secretion of neurotransmitters from neurons and hormones from endocrine cells. Exocytosis is highly regulated through the orchestrated actions of various proteins and lipids. It has been well recognized that protein kinase Cs (PKCs) are active regulators of exocytosis via phosphorylating multiple key proteins in the exocytotic cascade. The specific actions mediated by PKCs, however, have not been fully elucidated. The challenges mainly lie in the following aspects: 1) large variety of PKC isoforms and dubious specificity of the commonly used pharmacological tools; 2) large variety of PKC substrates; 4) difficulties to isolate the molecular steps in the highly dynamic exocytotic process. |
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Kim Kyong-Tai |
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Kim Kyong-Tai Xue, Renhao |
format |
Theses and Dissertations |
author |
Xue, Renhao |
author_sort |
Xue, Renhao |
title |
Protein kinase C in regulation of exocytosis |
title_short |
Protein kinase C in regulation of exocytosis |
title_full |
Protein kinase C in regulation of exocytosis |
title_fullStr |
Protein kinase C in regulation of exocytosis |
title_full_unstemmed |
Protein kinase C in regulation of exocytosis |
title_sort |
protein kinase c in regulation of exocytosis |
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2009 |
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https://hdl.handle.net/10356/19009 |
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1759854601825157120 |