New materials for drug delivery

• Main Author: Chua, Ming Fong.
• Other Authors: Andrew Clive Grimsdale
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Engineering
• Online Access: http://hdl.handle.net/10356/35819
• Institution: Nanyang Technological University

The success of anti-cancer therapy largely depends on the development of high-efficient, low toxic, long-circulating, and cancer-targeted drug delivery systems. Nanoparticles (NPs), an evolution of nanotechnology, have the potential to successfully address the problems of current drug delivery techniques. Hence nanoparticles are considered as potential candidates to carry drugs to the desired site of therapeutic action. This report focuses on the surface modification of nanoparticles through the use of surfactant Poly Vinyl Alcohol (PVA), Pyrophosphoric acid (PPA) and Bovine Serum Albumin (BSA). Surface modification of nanoparticles enhanced the attachment of targeted molecule with alkyne strycture through either one of its chain end namely; ester and amine functional group. Successfully synthesized product was characterized through nuclear magnetic resonance (NMR) before their attachment to surface modified nanoparticles. Fourier Transform Infrared spectroscopy (FTIR) was used to characterise the resultant product between the attachments of targeted alkyne compound to nanoparticles.