Effect of external stimuli on cell adhesion dynamics
210 p.
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2010
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| Online Access: | https://hdl.handle.net/10356/36028 |
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sg-ntu-dr.10356-360282023-03-11T17:46:45Z Effect of external stimuli on cell adhesion dynamics Feng, Zhiqin Kin Liao Vincent Chan School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering 210 p. Adhesion of cells to biomaterials or extracellular matrix (ECM) is a fundamental process in tissue engineering devices and biotechnological process, as well as in organogenesis and tissue maintenance. Anchorage-dependent cells adhering on surface modified with adhesive ligands will spread and undergoes cytoskeleton rearrangement. In turn, the cellular phenotypes of adherent cells on biomaterials are directly correlated with the biophysical responses of cells. However, the lack of integrated bio-analytics for probing the cell-substrate interface poses significant obstacles in the engineering analysis of cells on biomaterial or ECM surface. Based on the principle of confocal reflectance interference contrast microscopy (C-RICM), our group has successfully determined several key biophysical/biomechanical parameters of cells on model ECM. In this thesis, I apply the unique biophysical approaches on the elucidation of the effect of GFP-actin expression, Hepatitis B virus and cytoskeleton-targeting drugs on the biophysical behavior of HepG2 cells on a model ECM. DOCTOR OF PHILOSOPHY (MAE) 2010-04-23T02:24:17Z 2010-04-23T02:24:17Z 2006 2006 Thesis Feng, Z. Q. (2006). Effect of external stimuli on cell adhesion dynamics. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/36028 10.32657/10356/36028 application/pdf |
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Nanyang Technological University |
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Asia |
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Singapore Singapore |
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DRNTU::Engineering::Bioengineering |
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DRNTU::Engineering::Bioengineering Feng, Zhiqin Effect of external stimuli on cell adhesion dynamics |
| description |
210 p. |
| author2 |
Kin Liao |
| author_facet |
Kin Liao Feng, Zhiqin |
| format |
Theses and Dissertations |
| author |
Feng, Zhiqin |
| author_sort |
Feng, Zhiqin |
| title |
Effect of external stimuli on cell adhesion dynamics |
| title_short |
Effect of external stimuli on cell adhesion dynamics |
| title_full |
Effect of external stimuli on cell adhesion dynamics |
| title_fullStr |
Effect of external stimuli on cell adhesion dynamics |
| title_full_unstemmed |
Effect of external stimuli on cell adhesion dynamics |
| title_sort |
effect of external stimuli on cell adhesion dynamics |
| publishDate |
2010 |
| url |
https://hdl.handle.net/10356/36028 |
| _version_ |
1761782052106010624 |