Identification, analysis and evaluation of human fusion proteins of bacterial origin

172 p.

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Main Author: Yu, Yiting
Other Authors: Meena Kishore Sakharkar
Format: Theses and Dissertations
Published: 2010
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Online Access:https://hdl.handle.net/10356/36052
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-360522023-03-11T17:01:31Z Identification, analysis and evaluation of human fusion proteins of bacterial origin Yu, Yiting Meena Kishore Sakharkar School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering 172 p. Gene fusion is identified as a common phenomenon in the formation of new proteins. In order to better understand this evolutionary trend, we first designed a methodology for the identification of fusion proteins (the composite proteins) consisting of two or more fusion partners (the component proteins). We then applied the designed methodology to identify human fusion proteins of bacterial origin in the human genome. We thus obtained a comprehensive list of 141 putative human composite proteins consisting of component proteins (or domains) of bacterial origin. The 141 identified human fusion proteins were visually inspected and manually mapped to metabolic pathways using the KEGG pathway database interface. We thus selected six fusion proteins that function as metabolic enzymes in the citric acid cycle. DOCTOR OF PHILOSOPHY (MAE) 2010-04-23T02:25:34Z 2010-04-23T02:25:34Z 2007 2007 Thesis Yu, Y. T. (2007). Identification, analysis and evaluation of human fusion proteins of bacterial origin. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/36052 10.32657/10356/36052 application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Yu, Yiting
Identification, analysis and evaluation of human fusion proteins of bacterial origin
description 172 p.
author2 Meena Kishore Sakharkar
author_facet Meena Kishore Sakharkar
Yu, Yiting
format Theses and Dissertations
author Yu, Yiting
author_sort Yu, Yiting
title Identification, analysis and evaluation of human fusion proteins of bacterial origin
title_short Identification, analysis and evaluation of human fusion proteins of bacterial origin
title_full Identification, analysis and evaluation of human fusion proteins of bacterial origin
title_fullStr Identification, analysis and evaluation of human fusion proteins of bacterial origin
title_full_unstemmed Identification, analysis and evaluation of human fusion proteins of bacterial origin
title_sort identification, analysis and evaluation of human fusion proteins of bacterial origin
publishDate 2010
url https://hdl.handle.net/10356/36052
_version_ 1761781221228019712