Synthetic studies towards bistramide D
Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasiti...
Saved in:
| 主要作者: | |
|---|---|
| 其他作者: | |
| 格式: | Theses and Dissertations |
| 語言: | English |
| 出版: |
2010
|
| 主題: | |
| 在線閱讀: | https://hdl.handle.net/10356/38774 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|
| 機構: | Nanyang Technological University |
| 語言: | English |
| 總結: | Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasitic properties; the recent studies also show that bistramides bind to Actin. Bistramide A was reported to be very potent for the P388/dox, B16, HT29, and NSCLC-N6 cell lines. Bistramide D has similar activity in the NSCLC-N6 cell line but is comparatively less toxic in vivo. There has been no total synthesis of bistramide D reported till now to our knowledge. These intriguing biological profiles and challenging molecular architecture of bistramides motivated us to synthesize bistramide D. |
|---|