Synthetic studies towards bistramide D

• Main Author: Kalpana Palani
• Other Authors: Roderick Wayland Bates
• Format: Theses and Dissertations
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: https://hdl.handle.net/10356/38774
• Institution: Nanyang Technological University

Bistramide D is a member of new class of bioactive molecule isolated from the marine ascidian Lissoclinum bistratum in New Caledonia. Bistramides (A, B, C, D and K) show a broad spectrum of biological activity which includes antiproliferative, immunomodulatory, neurotoxic, cytotoxic and antiparasitic properties; the recent studies also show that bistramides bind to Actin. Bistramide A was reported to be very potent for the P388/dox, B16, HT29, and NSCLC-N6 cell lines. Bistramide D has similar activity in the NSCLC-N6 cell line but is comparatively less toxic in vivo. There has been no total synthesis of bistramide D reported till now to our knowledge. These intriguing biological profiles and challenging molecular architecture of bistramides motivated us to synthesize bistramide D.