Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process

In this work, a separation of Guaifenesin via the use of a Simulated Moving Bed (SMB) process was modeled. An SMB process was designed, using the equilibrium theory to estimate the flow rates in the different sections of the SMB. Equilibrium theory is a simplified model of the SMB process, neglectin...

Full description

Saved in:
Bibliographic Details
Main Author: Tian, Xue Yuan.
Other Authors: Mohammad Aman Ullah
Format: Final Year Project
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/39612
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-39612
record_format dspace
spelling sg-ntu-dr.10356-396122023-03-03T15:36:26Z Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process Tian, Xue Yuan. Mohammad Aman Ullah School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering In this work, a separation of Guaifenesin via the use of a Simulated Moving Bed (SMB) process was modeled. An SMB process was designed, using the equilibrium theory to estimate the flow rates in the different sections of the SMB. Equilibrium theory is a simplified model of the SMB process, neglecting axial dispersion and mass transfer resistances. This idealization of the model resulted in some differences between the complete separation region of the simulation and that predicted using the equilibrium theory. This work uses a switch time of 90 seconds, columns of 1 cm internal diameter and 10 cm in length in a 1:1:1:1 configuration. Performance of the SMB was assessed based on four performance parameters, namely purity and recovery of outlet streams, solvent consumption and productivity of stationary phase. Based on the results, it was concluded that equilibrium theory is a good estimation for the SMB process, and can be used as a fairly accurate shortcut design method to design an SMB. Nonlinear operating conditions was also chosen over linear conditions for an industrial scale separation of Guaifenesin, due to the lower solvent consumption and higher productivity of operations at nonlinear conditions, while achieving at least 95% purity in both the extract and raffinate streams. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-06-01T07:31:32Z 2010-06-01T07:31:32Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39612 en Nanyang Technological University 52 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Chemical engineering
spellingShingle DRNTU::Engineering::Chemical engineering
Tian, Xue Yuan.
Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
description In this work, a separation of Guaifenesin via the use of a Simulated Moving Bed (SMB) process was modeled. An SMB process was designed, using the equilibrium theory to estimate the flow rates in the different sections of the SMB. Equilibrium theory is a simplified model of the SMB process, neglecting axial dispersion and mass transfer resistances. This idealization of the model resulted in some differences between the complete separation region of the simulation and that predicted using the equilibrium theory. This work uses a switch time of 90 seconds, columns of 1 cm internal diameter and 10 cm in length in a 1:1:1:1 configuration. Performance of the SMB was assessed based on four performance parameters, namely purity and recovery of outlet streams, solvent consumption and productivity of stationary phase. Based on the results, it was concluded that equilibrium theory is a good estimation for the SMB process, and can be used as a fairly accurate shortcut design method to design an SMB. Nonlinear operating conditions was also chosen over linear conditions for an industrial scale separation of Guaifenesin, due to the lower solvent consumption and higher productivity of operations at nonlinear conditions, while achieving at least 95% purity in both the extract and raffinate streams.
author2 Mohammad Aman Ullah
author_facet Mohammad Aman Ullah
Tian, Xue Yuan.
format Final Year Project
author Tian, Xue Yuan.
author_sort Tian, Xue Yuan.
title Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
title_short Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
title_full Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
title_fullStr Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
title_full_unstemmed Optimization of continuous binary separation of guaifenesin using simulated moving bed (SMB) process
title_sort optimization of continuous binary separation of guaifenesin using simulated moving bed (smb) process
publishDate 2010
url http://hdl.handle.net/10356/39612
_version_ 1759855646575951872