Computational modeling of ErbB kinase oligomeric state.

• Main Author: Lim, Sing Mei.
• Other Authors: Chandra Shekhar Verma
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biomathematics
• Online Access: http://hdl.handle.net/10356/39789
• Institution: Nanyang Technological University

Epidermal growth factor receptor (EGFR), a member of ErbB family, has been recently proposed to be activated allosterically through asymmetric dimerization of the kinase domain. This study aimed to first investigate whether the reported configuration of asymmetric assembly is conserved across the Er...