Dynamic optimization of batch processes.

Batch processes are common in the pharmaceuticals, specialty and fine chemicals industries. Unlike continuous processes, batch processes are dynamic in nature. Therefore, they are often not operated with the control variables at fixed setpoints. Instead, control trajectories that vary with time are...

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Main Author: Lim, Wee Kiat.
Other Authors: Vinay Kumar Kariwala
Format: Final Year Project
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/39791
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-397912023-03-03T15:39:59Z Dynamic optimization of batch processes. Lim, Wee Kiat. Vinay Kumar Kariwala School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Processes and operations Batch processes are common in the pharmaceuticals, specialty and fine chemicals industries. Unlike continuous processes, batch processes are dynamic in nature. Therefore, they are often not operated with the control variables at fixed setpoints. Instead, control trajectories that vary with time are often implemented to transfer the systems from their initial states to their final states. Process optimization has the potential to achieve (i) savings from lowering of production costs; (ii) improvement in product quality; and (iii) ensuring product consistency. In this work, the fundamentals of dynamic optimization and its application to improve operation of batch processes were explored. The simultaneous approach was used to determine the optimal control trajectories for a fed-batch bioreactor and a batch cooling crystallizer. Through the examples, it was shown that improvements in batch performance can be obtained through the application of dynamic optimization. 2 important issues in dynamic optimization were also studied, namely (i) singular optimal control problem; and (ii) effect of parametric uncertainty on the optimization of the batch operation. Several techniques that are proposed in the literatures to handle such issues were reviewed and their effectiveness was tested with the examples. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-06-04T03:22:24Z 2010-06-04T03:22:24Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39791 en Nanyang Technological University 77 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Chemical engineering::Processes and operations
spellingShingle DRNTU::Engineering::Chemical engineering::Processes and operations
Lim, Wee Kiat.
Dynamic optimization of batch processes.
description Batch processes are common in the pharmaceuticals, specialty and fine chemicals industries. Unlike continuous processes, batch processes are dynamic in nature. Therefore, they are often not operated with the control variables at fixed setpoints. Instead, control trajectories that vary with time are often implemented to transfer the systems from their initial states to their final states. Process optimization has the potential to achieve (i) savings from lowering of production costs; (ii) improvement in product quality; and (iii) ensuring product consistency. In this work, the fundamentals of dynamic optimization and its application to improve operation of batch processes were explored. The simultaneous approach was used to determine the optimal control trajectories for a fed-batch bioreactor and a batch cooling crystallizer. Through the examples, it was shown that improvements in batch performance can be obtained through the application of dynamic optimization. 2 important issues in dynamic optimization were also studied, namely (i) singular optimal control problem; and (ii) effect of parametric uncertainty on the optimization of the batch operation. Several techniques that are proposed in the literatures to handle such issues were reviewed and their effectiveness was tested with the examples.
author2 Vinay Kumar Kariwala
author_facet Vinay Kumar Kariwala
Lim, Wee Kiat.
format Final Year Project
author Lim, Wee Kiat.
author_sort Lim, Wee Kiat.
title Dynamic optimization of batch processes.
title_short Dynamic optimization of batch processes.
title_full Dynamic optimization of batch processes.
title_fullStr Dynamic optimization of batch processes.
title_full_unstemmed Dynamic optimization of batch processes.
title_sort dynamic optimization of batch processes.
publishDate 2010
url http://hdl.handle.net/10356/39791
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