Iron-catalyzed α-amidation of heterocycles with potential route to amino alcohols, amino thiols, and diamino products by nucleophilic ring opening.

• Main Author: Tania, Stefani.
• Other Authors: Philip Wai Hong Chan
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: http://hdl.handle.net/10356/39888
• Institution: Nanyang Technological University

An efficient method for α-amidation of heterocyclic moieties via direct nitrene insertion catalyzed by iron(III)trifluoromethanesulfonate with PhI=NTs (Ts = p-toluenesulfonyl)as a nitrogen source is reported herein. This reaction was shown to be applicable to cyclic ethers, cyclic thioethers, and py...