Polycaprolactone scaffold fabricated via selective laser sintering for cardiac tissue engineering
Cardiac tissue engineering has been emerged as one of the promising area in the biomedical engineering to repair or replace damaged tissue. It focused on growing cells by using temporary three – dimensional biomaterial scaffold acting as a support to guide cell proliferation. An advanced scaffold...
محفوظ في:
المؤلف الرئيسي: | |
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مؤلفون آخرون: | |
التنسيق: | Final Year Project |
اللغة: | English |
منشور في: |
2010
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الموضوعات: | |
الوصول للمادة أونلاين: | http://hdl.handle.net/10356/40434 |
الوسوم: |
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المؤسسة: | Nanyang Technological University |
اللغة: | English |
الملخص: | Cardiac tissue engineering has been emerged as one of the promising area in the
biomedical engineering to repair or replace damaged tissue. It focused on growing
cells by using temporary three – dimensional biomaterial scaffold acting as a support
to guide cell proliferation. An advanced scaffold fabrication technique such as Rapid
Prototyping (RP) processed has been utilized to overcome the limitation of the
conventional base method. Selective Laser Sintering was utilized to fabricate tissue
engineering scaffolds due to its high reproducibility and good control of pore size.
Polycaprolactone (PCL) is a semicrystalline polymer that has been proven as a
biocompatible and bioresorbable material for tissue engineering applications. In this
report, it is aimed to show that by varying the sintering parameter of the SLS system,
mechanical properties in the tensile mode of the PCL scaffold can be changed to
obtain low stiffness. The SLS parameters named laser power, laser scan speed and
part bed temperature were varied. The laser power between 1 – 5 W, the laser scan
speed between 100 – 300 inch/s and constant part bed temperature of 50 °C were
tested. The Young’s modulus of PCL scaffold varied from 3 MPa to 42 MPa and the
maximum elongation varied from 12 % to 162 %. Fracture surface of the scaffold
after break was also investigated to know the failure mode and avoid catastrophic
failure. Although it was shown that SLS is feasible to fabricate PCL scaffold, the
mechanical properties has not reached the target in order of tens kPa. Thus, further
process need to be carried out to fabricate the scaffold that match with the tensile
stiffness of the native myocardium. |
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