Non-invasive blood flow measurement using diffuse correlation spectroscopy

Diffuse Correlation Spectroscopy (DCS) is an emerging method that measures blood flow in small vessels of deep tissue non-invasively. It uses the dynamic fluctuations of speckle pattern formed by photons that are scattered by blood cells. Possible DCS applications include stroke monitoring, breast c...

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Main Author: Melda.
Other Authors: Lee Kijoon
Format: Final Year Project
Language:English
Published: 2010
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Online Access:http://hdl.handle.net/10356/40445
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-404452023-03-03T15:32:13Z Non-invasive blood flow measurement using diffuse correlation spectroscopy Melda. Lee Kijoon School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biosensors Diffuse Correlation Spectroscopy (DCS) is an emerging method that measures blood flow in small vessels of deep tissue non-invasively. It uses the dynamic fluctuations of speckle pattern formed by photons that are scattered by blood cells. Possible DCS applications include stroke monitoring, breast cancer diagnosis, and brain functional imaging. The purpose of the author’s project was to build a single channel DCS device and validate its performance by doing several control experiments. Several control experiments with simulated particle motions and a subsequent in-vivo experiment with cuff occlusion were conducted. The results generated from the established DCS device were the inverse of theoretical expectation. However, qualitatively, the device was able to detect changes of blood flow. The reason of this discrepancy is discussed in the text. In addition, the author was able to develop real time DCS data acquisition and analysis program which can be used for continuous monitoring of relative blood flow over time. In summary, the DCS device which was built offers a promising possibility for continuous blood flow monitoring. Several improvements on the device were still required for obtaining better measurements. This project could eventually be combined with Diffuse Optical Tomography (DOT) which measures deep tissue hemodynamic variables non-invasively. This instrument can provide a non-invasive measurement of local metabolic rate thereby enabling more accurate functional imaging of human body. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-06-15T09:11:39Z 2010-06-15T09:11:39Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/40445 en Nanyang Technological University 61 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Biosensors
spellingShingle DRNTU::Science::Medicine::Biosensors
Melda.
Non-invasive blood flow measurement using diffuse correlation spectroscopy
description Diffuse Correlation Spectroscopy (DCS) is an emerging method that measures blood flow in small vessels of deep tissue non-invasively. It uses the dynamic fluctuations of speckle pattern formed by photons that are scattered by blood cells. Possible DCS applications include stroke monitoring, breast cancer diagnosis, and brain functional imaging. The purpose of the author’s project was to build a single channel DCS device and validate its performance by doing several control experiments. Several control experiments with simulated particle motions and a subsequent in-vivo experiment with cuff occlusion were conducted. The results generated from the established DCS device were the inverse of theoretical expectation. However, qualitatively, the device was able to detect changes of blood flow. The reason of this discrepancy is discussed in the text. In addition, the author was able to develop real time DCS data acquisition and analysis program which can be used for continuous monitoring of relative blood flow over time. In summary, the DCS device which was built offers a promising possibility for continuous blood flow monitoring. Several improvements on the device were still required for obtaining better measurements. This project could eventually be combined with Diffuse Optical Tomography (DOT) which measures deep tissue hemodynamic variables non-invasively. This instrument can provide a non-invasive measurement of local metabolic rate thereby enabling more accurate functional imaging of human body.
author2 Lee Kijoon
author_facet Lee Kijoon
Melda.
format Final Year Project
author Melda.
author_sort Melda.
title Non-invasive blood flow measurement using diffuse correlation spectroscopy
title_short Non-invasive blood flow measurement using diffuse correlation spectroscopy
title_full Non-invasive blood flow measurement using diffuse correlation spectroscopy
title_fullStr Non-invasive blood flow measurement using diffuse correlation spectroscopy
title_full_unstemmed Non-invasive blood flow measurement using diffuse correlation spectroscopy
title_sort non-invasive blood flow measurement using diffuse correlation spectroscopy
publishDate 2010
url http://hdl.handle.net/10356/40445
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