Drug-herb interactions on pseudomonas aeruginosa
The aim of this study was to determine if synergism was observed for various combinations of antibiotics with the phytomedicines against American Type Culture Collection (ATCC) strain of P.aeruginosa. The minimum inhibitory concentration (MIC) of these antibiotics and phytomedicines were de...
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| Main Author: | |
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| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/41442 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The aim of this study was to determine if synergism was observed for various
combinations of antibiotics with the phytomedicines against American Type Culture
Collection (ATCC) strain of P.aeruginosa. The minimum inhibitory concentration
(MIC) of these antibiotics and phytomedicines were determined by microdilution method. The results from both the checkerboard and killing curve methodologies by microdilution method were compared. The results of this study indicate that against P.aeruginosa, synergism is observed in combination with some western antibiotics and phytomedicines. Synergism appears to be maintained even at very high MICs with drug concentrations within achievable therapeutic ranges. With current definitions of synergism there was absolute correlation between the results obtained by the checkerboard and killing curve methodologies, with the fractional inhibitory
concentration indices and killing curves resulting in synergism. No antagonism was
observed. |
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