Formulation of particles for pulmonary drug delivery

• Main Author: Meer Saiful Hassan
• Other Authors: Lau Wai Man Raymond
• Format: Theses and Dissertations
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology; DRNTU::Engineering::Chemical engineering::Biotechnology
• Online Access: https://hdl.handle.net/10356/41683
• Institution: Nanyang Technological University

Pulmonary drug delivery has become an attractive route of drug administration to the human body for the treatment of lung diseases and a number of systemic applications. Dry powder inhalation (DPI) is considered as the most appropriate aerosol therapeutics in terms of delivery efficiency, patient compliance and environmental issue. Successful delivery of the dry powder formulation to the deep lung requires proper understanding of the factor influencing particle deposition. Improvement of the drug formulation characteristics is the most convenient way to control delivery performance. In this study, the effect of shape and morphology of dry particles for inhalation is investigated. The optimum design of micro-particle for better delivery performance is determined.