Development of SARS-COV therapeutics using quaternary protein mimetics

• Main Author: Neo, Tuan Ling
• Other Authors: James P. Tam
• Format: Theses and Dissertations
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/41875
• Institution: Nanyang Technological University

SARS-CoV, a novel virus belonging to group IV coronavirus, was discovered in association with cases of severe acute respiratory syndrome (SARS) in 2003. The spike (S) protein of SARS-CoV is responsible for receptor binding and membrane fusion. The MPER, the Trp-rich membrane proximal external region...