Engineering chondrogenesis with chondroprogenitor/stem cells in gene-transferred co-culture system
Cartilage restoration continues to present a tremendous clinical challenge due to its nonvascular nature. Many studies have demonstrated that chondrogenesis of progenitor cells can be achieved in vitro by manual dose of growth factors; however it remains a vital difficulty in feeding growth factors...
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| Format: | Research Report |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/41876 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Cartilage restoration continues to present a tremendous clinical challenge due to its nonvascular nature. Many studies have demonstrated that chondrogenesis of progenitor cells can be achieved in vitro by manual dose of growth factors; however it remains a vital difficulty in feeding growth factors to implanted therapeutic cells in vivo. The current project aims at cartilage tissue engineering through a co-culture system, in which, genedelivered
de-differentiated chondrocytes (The Transfected Companion Cells, TCCs) provide sustained, localized and over-expressed growth factors to mesenchymal stem cells (MSCs) (The Therapeutic Progenitor Cells, TPCs) , and thus induce MSCs to differentiate into chondrocytes. |
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